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Vaccine Weekly

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DNA Vaccines



Recent findings from Central South University highlight research in DNA vaccines



January 14th, 2009

"To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this protection. In this study, pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial infection," investigators in Changsha, People's Republic of China report.

"Groups of BALB/c mice were immunized intranasally with pORF5 DNA vaccine. Humoral and cell mediated immune responses were evaluated. The clearance ability of chlamydial challenge from the genital tract and the chlamydia-induced upper genital tract gross pathology and histopathological characterization were also detected. The results showed...


Source: Vaccine Weekly (2009-01-14)

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