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Life Sciences
Studies conducted at University of Ulm on life sciences recently published
January 21st, 2009
According to a study from Ulm, Germany, "Only small populations of nonactivated, nonproliferating Foxp3(+) CD4 regulatory T cell (T-R) cells are found in the nonparenchymal cell compartment of the mouse liver while liver-draining celiac nodes contain expanded, activated TR cell populations (similar to other lymph nodes). Liver Foxp3(+) CD4 T-R cells suppress activation of T cell responses." "Polyclonal, systemic T cell activation in vivo (via anti-CD3 antibody injection) is accompanied by intrahepatic accumulation of T blasts and a rapid but transient intrahepatic increase of activated, proliferating Foxp3(+) CD4 T-R cells. Following vaccination, the appearance of...
Source: Vaccine Weekly (2009-01-21)
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