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HIV/AIDS
Research data from A. Cagigi and colleagues update understanding of HIV/AIDS
January 21st, 2009
"HIV-1 infection is associated with B-cell abnormalities, such as hypergamma-globulinemia, poor immunization responses, and loss of serologic memory. To determine whether altered expression of chemokine receptors and their ligands may play a role in B-cell dysfunctions during HIV-1 infection, the expression of CXC chemokine receptor 4 (CXCR4), CXCR5, and CC chemokine receptor 7 (CCR7) and their respective ligands on CD19(+) B cells were examined in HIV-1-infected patients and controls," scientists in Stockholm, Sweden report. "We report a decreased CXCR5 expression on B cells from patients (P < .05), a phenomenon associated with a low CD4 T-cell count (< 350...
Source: Vaccine Weekly (2009-01-21)
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