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Life Sciences
Studies from S. He et al have provided new data on life sciences
January 21st, 2009
According to recent research published in the Journal of Leukocyte Biology, "Acquisition of dendritic cells (DCs) or DC precursors in vitro is critical for DC-based immunotherapy. We reported previously that administration of MIP-1 alpha mobilized a population of F4/80(-)B220(-)CD11c(+) DC precursors into peripheral blood by the expression of CCR1 and CCR5." "In this study, we identified a new subset of CCR6(+) CCR1(-) CCR5(-)B220(-)CD11c(+) cells in MIP-1 alpha-administered mice. When cultured with GM-CSF, IL-4, and TNF-alpha, these cells differentiated into mature DCs, possessing the typical morphologic characteristics, phenotypes, and antigenpresenting...
Source: Vaccine Weekly (2009-01-21)
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