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Vaccinia Virus
Studies from University of Paris provide new data on vaccinia virus
January 21st, 2009
"Unlike most DNA viruses, poxviruses replicate in the cytoplasm of host cells. They encode enzymes needed for genome replication and transcription, including their own thymidine and thymidylate kinases," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Some herpes viruses encode only 1 enzyme catalyzing both reactions, a peculiarity used for prodrug activation to obtain maximum specificity. We have solved the crystal structures of vaccinia virus thymidylate kinase bound to TDP or brivudin monophosphate. Although the viral and human enzymes have similar sequences (42% identity), they differ...
Source: Vaccine Weekly (2009-01-21)
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