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HIV/AIDS Vaccines
Researchers at University of the Basque Country publish new data on HIV/AIDS vaccines
January 21st, 2009
A new study, 'Lipid modulation of membrane-bound epitope recognition and blocking by HIV-1 neutralizing antibodies,' is now available. According to recent research published in the journal FEBS Letters, "The conserved, aromatic-rich membrane-proximal external region (MPER) of gp41 is functional in human immunodeficiency virus (HIV)-cell fusion by perturbing membrane integrity. Broadly-neutralizing 2F5 and 4E10 monoclonal antibodies (MAb-s) recognize amino-and carboxy-terminal epitope sequences within this domain, respectively." "An MPER peptide overlapping 2F5 and 4E10 epitope sequences was capable of breaching the permeability barrier of lipid vesicles....
Source: Vaccine Weekly (2009-01-21)
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