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Vaccines
Researchers from Food & Drug Administration, Division of Viral Products discuss findings in vaccines
January 21st, 2009
New research, 'Attenuated West Nile viruses bearing 3'SL and envelope gene substitution mutations,' is the subject of a report. "Four viable West Nile (WN) 3'SL-mutant viruses were evaluated for neuroinvasiveness and neurovirulence in mice. All mutants were highly attenuated for neuroinvasiveness," scientists writing in the journal Vaccine report. "However, only one of these four (WNmutE virus) was significantly attenuated for neurovirulence. To attenuate WNmutE virus further, we introduced five substitution mutations into the envelope (env) gene segment in wild-type (wt) WN and WNmutE genomes, based on differences in the env gene sequence between the live...
Source: Vaccine Weekly (2009-01-21)
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