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Falciparum Malaria
Investigators at Pennsylvania State University, Medical Department have published new data on falciparum malaria
January 21st, 2009
According to recent research published in the journal Biochemistry, "Infection with Plasmodium falciparum during pregnancy results in the adherence of infected red blood cells (IRBCs) in placenta, causing pregnancy-associated malaria with severe health complications in mothers and fetuses. The chondroitin 4-sulfate (C4S) chains of very low sulfated chondroitin sulfate proteoglycans (CSPGs) in placenta mediate the IRBC adherence." "While it is known that partially sulfated but not fully sulfated C4S effectively binds IRBCs, structural interactions involved remain unclear and are incompletely understood. In this study, structurally defined C4S oligosaccharides of...
Source: Vaccine Weekly (2009-01-21)
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