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Falciparum Malaria
Studies from I. Viganwomas et al provide new data on falciparum malaria
January 21st, 2009
"In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting), form autoagglutinates, and have a high multiplication rate, three phenotypic characteristics that are associated with severe malaria in human patients. We report here that varO parasites express a var gene having the characteristics of group A var genes, and we show that the varO Duffy binding-like 1 alpha(1) (DBL1 alpha(1)) domain is implicated in the rosetting of both S. sciureus and human erythrocytes," scientists in Paris, France report. "The soluble varO N-terminal sequence (NTS)-DBL1...
Source: Vaccine Weekly (2009-01-21)
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