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Melanoma
Study findings from I. Magalhaes et al provide new insights into melanoma
January 28th, 2009
According to a study from Solna, Sweden, "CD8(+) T-cell memory formation has recently been demonstrated to be associated with CD8 alpha alpha homodimer expression by T-cells in mice. Up to now, the knowledge about the clinical significance of CD8 alpha alpha(+) T-cells in humans is limited." "We assessed in longitudinally collected blood samples from patients with melanoma, who underwent a peptide-based vaccination, the role of CD8 alpha alpha(+) T-cells in tumor-specific cellular immune responses. Phenotypic analysis showed that the expression of CD8 alpha alpha(+) by T-cells was stable over time and associated with a CD45RA(+/-)CCR7(-) effector-memory profile....
Source: Vaccine Weekly (2009-01-28)
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