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Immunology
New immunology study findings recently were published by investigators at Baylor Institute for Immunology Research
January 28th, 2009
A report, 'A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts,' is newly published data in Immunity. "Mucosal immunoglobulin A (IgA) secreted by local plasma cells (PCs) is a critical component of mucosal immunity. Although IgA class switching can occur at mucosal sites, high-affinity PCs are optimally generated in germinal centers (GCs) in a T cell-dependent fashion," researchers in the United States report. "However, how CD4(+) helper T cells induce mucosal-homing IgA-PCs remains unclear. Here, we show that transforming growth factor beta1 (TGFbeta1) and interleukin 21 (IL-21), produced by follicular...
Source: Vaccine Weekly (2009-01-28)
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