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Lupus Vaccines
Report summarizes lupus vaccines study findings from Oklahoma Medical Research Foundation
January 28th, 2009
A new study, 'Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments,' is now available. "Epstein-Barr virus has been implicated in the etiology of systemic lupus erythematosus (SLE) through serologic and immunologic studies. A potential mechanism for this influence is through molecular mimicry," researchers in the United States report. "The EBV nuclear antigen EBNA-1 contains a region, PPPGRRP, with considerable homology to the initial sequence targeted by antibodies in Sm B' autoimmunity, PPPGMRPP. This study examined whether immunization of rabbits and mice with peptides containing the PPPGRRP sequence from EBNA-1 constructed...
Source: Vaccine Weekly (2009-01-28)
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