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Vaccine Weekly

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Adverse Drug Reactions



Research conducted at K.S. Kohl and co-researchers has updated our knowledge about adverse drug reactions



January 28th, 2009

"We evaluated the applicability, reliability, sensitivity, and specificity of six standardized case definitions for adverse events following immunization (AEFI) (for fever, generalized Convulsive seizure, hypotonic-hyporesponsive episode, intussusception, nodule, and persistent crying) developed by the Brighton Collaboration using the U.S. Vaccine Adverse Event Reporting System (VAERS)," researchers in the United States report.

"The evaluation included: (a) the development of codified search strings using standardized coding terminology, and (b) for sensitivity and specificity analyses, the development of a ''gold standard'' for case determination by clinical expert...


Source: Vaccine Weekly (2009-01-28)

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