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Foot and Mouth Disease
Reports summarize foot and mouth disease study results from Autonomous University
January 28th, 2009
According to recent research from Madrid, Spain, "We have rationally engineered foot-and-mouth disease virus to increase its stability against thermal dissociation into subunits without disrupting the many biological functions needed for its infectivity. Amino acid side chains located near the capsid intersubunit interfaces and either predicted or found to be dispensable for infectivity were replaced by others that could establish new disulfide bonds or electrostatic interactions between subunits." "Two engineered viruses were normally infectious, genetically stable, and antigenically indistinguishable from the natural virus but showed substantially increased stability...
Source: Vaccine Weekly (2009-01-28)
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