Immunization
Studies from Catholic University in the area of immunization described
Published in Vaccine Weekly, January 28th, 2009
According to recent research from Seoul, South Korea, "Carcinoembryonic antigen (CEA) is expressed on human colon carcinomas, is well characterized, and continues to be a promising target for cancer immunotherapy in humans. To enhance the in immunogenecity of CEA, we developed a fusion gene (CRT-TAT-Delta CEA) of the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid of its signal sequences (ACEA)and evaluated anti-tumor immunity using RNA-pulsed dendritic cell (DC) vaccination."
"Mice vaccinated with DC by electroporation with mRNA encoding TAT-ACEA (DC/TAT-Delta CEA) and CRT-Delta CEA (DC/CRT-Delta CEA) had enhanced induction of...
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Source: Vaccine Weekly (2009-01-28)
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