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Brain Cancer
Study results from Pennsylvania State University update understanding of brain cancer
January 28th, 2009
According to a study from the United States, "Adoptive cell transfer has been shown to significantly reduce established tumors in both experimental models and cancer patients. Owing to the tolerogenic nature of cancer approaches that lead to durable maintenance of functional T cells in tumor-bearing hosts are needed to maximize tumor regression." "In this study, we investigated strategies to augment CD8(+) T-cell (T-CD8)-mediated adoptive immunotherapy of mice bearing advanced-stage autochthonous brain tumors by targeting a weakly immunogenic epitope. We found that immunization enhanced the accumulation of adoptively transferred T-CD8 at the tumor site, but that the...
Source: Vaccine Weekly (2009-01-28)
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