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Biotechnology
Research from Institute for Biotechnology yields new findings on biotechnology
February 4th, 2009
Research findings, 'High frequency plasmid recombination mediated by 28 bp direct repeats,' are discussed in a new report. "The stability in Escherichia coli of a mammalian expression vector (pCIneo) and its derivative candidate DNA vaccine (pGPV-PV) is described. These multicopy pMB1-type plasmids were found to recombine in several recA E. coli strains due to the presence of two 28 bp direct repeats flanking intervening sequences of 1.6 kb (pCIneo) and 3.2 kb (pGPV-PV)," researchers in Lisbon, Portugal report. "In this recombination event, one of the direct repeats and the intervening sequence were deleted or duplicated, originating monomeric or/and...
Source: Vaccine Weekly (2009-02-04)
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