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Vaccines
New findings in vaccines described from University of Colorado
February 4th, 2009
"It has been suggested that agglomeration of aluminum salt adjuvant particles during freezing and drying can cause loss of immunogenicity of vaccines formulated with such adjuvants," scientists in the United States report. "In this study, we tested this hypothesis and examined the immune response in a murine model to various liquid, freeze-thawed, and lyophilized vaccine formulations, using lysozyme as a model antigen. The various processing techniques and excipient levels resulted in a wide range of particle size distributions (PSDs) and antigen-adjuvant binding levels," wrote A. Clausi and colleagues, University of Colorado. The researchers...
Source: Vaccine Weekly (2009-02-04)
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