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Vaccine Weekly

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Immunization



Scientists at University of Minnesota describe research in immunization



February 11th, 2009

"Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination, protect the host against specific viral infections(1). It has long been proposed that the number of memory CD8 T cells in the host is inflexible, and that individual cells are constantly competing for limited space(2,3)," researchers in the United States report.

"Consequently, vaccines that introduce over- abundant quantities of memory CD8 T cells specific for an agent of interest could have catastrophic consequences for the host by displacing memory CD8 T cells specific for all previous infections(4-6). To test this paradigm, we developed a vaccination regimen in mice that...


Source: Vaccine Weekly (2009-02-11)

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