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Vaccine Weekly

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Vaccines



Research from A.M. Ali and co-researchers in the area of vaccines published



February 11th, 2009

"In this Study potential molecular markers for identification of attenuation in a Theileria lestoquardi-infected cell line to be used in vaccination trials were identified. Two markers associated with attenuation in Theileria annulata vaccine strains were analyzed (metalloproteinase activity and TNF alpha mRNA expression)," scientists writing in the journal Vaccine report.

"The result showed a decreased activity of MMP 9 and decreased mRNA expression of TNF alpha with increasing passage number. Suppression subtractive hybridization was used to identify potential new markets of attenuation. Random screening revealed nine differentially expressed genes, one from...


Source: Vaccine Weekly (2009-02-11)

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