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DNA Vaccines
Scientists at Montana State University release new data on DNA vaccines
February 11th, 2009
According to recent research from the United States, "Pneumonic plague remains problematic in endemic areas, and because it can be readily transmitted and has high mortality, the development of efficacious vaccines is warranted. To test whether stimulation of cell-mediated immunity with IL-12 will improve protective immunity against plague, we constructed two IL-12 DNA vaccines using a bicistronic plasmid encoding the protective plague epitopes, capsular(F1) antigen and virulence antigen (V-Ag) as F1-V fusion protein and V-Ag only, respectively." "When applied intramuscularly, antibody responses to F1- and V-Ag were detectable beginning at week 6 after 3 weekly doses,...
Source: Vaccine Weekly (2009-02-11)
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