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Yellow Fever
Data on yellow fever reported by researchers at Emory Vaccine Center
February 18th, 2009
According to recent research published in the journal Nature Immunology, "A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D." "Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of the integrated stress response-that correlated with and predicted YF-17D CD8(+) T...
Source: Vaccine Weekly (2009-02-18)
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