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Life Sciences
Scientists at University of Melbourne release new data on life sciences
February 18th, 2009
"Understanding T cell immunodominance hierarchies is fundamental to the development of cellular-based vaccines and immunotherapy. A combination of influenza virus infection in C57BL/6J mice and reverse genetics is used here to dissect the role of T cell antigen receptor (TCR) repertoire in the immunodominant D(b)NP(366)CD8(+) T cell response," scientists in Melbourne, Australia report. "Infection with an engineered virus (NPM6A) containing a single alanine (A) mutation at the critical p6 NP366-374 residue induced a noncross-reactive CD8(+) T cell response characterized by a novel, narrower TCR repertoire per individual mouse that was nonetheless equivalent in magnitude...
Source: Vaccine Weekly (2009-02-18)
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