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Cancer Vaccines Immunology
Research on cancer vaccines immunology reported by F. Meklat et al
February 18th, 2009
A new study, 'Identification of protamine 1 as a novel cancer-testis antigen in early chronic lymphocytic leukaemia,' is now available. According to a study from the United States, "Early chronic lymphocytic leukaemia (CLL) is an ideal disease for immunotherapy. We previously showed that SEMG 1 is a cancer-testis (CT) antigen in CLL." "In this study, SEMG 1 was applied as the bait in a yeast two-hybrid system of a testicular cDNA library. Seven clones were isolated and Protamine (Prm) 1 was identified as a novel CT antigen in early CLL. PRM1 transcripts were detected in 11/41 (26.8%) patients. Prm 1 protein was also expressed but heterogeneously within individual...
Source: Vaccine Weekly (2009-02-18)
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