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DNA Vaccines
Reports outline DNA vaccines study results from D.S.W. Ow et al
February 25th, 2009
"Well-characterized derivatives of Escherichia coli K12 such as DHS alpha are the host strains commonly used for plasmid DNA production. Owing to the prospective clinical demand for large quantities of plasmid DNA for gene therapy and DNA vaccination, existing plasmid production processes need to be optimized to attain higher plasmid yields," scientists in Singapore, Singapore report. "To date, nearly all production optimization efforts are focused on media or fermentation process design. Although there has been a simple empirical evaluation of the available host strains, there is a lack of systematic effort at engineering these host strains for improved plasmid DNA...
Source: Vaccine Weekly (2009-02-25)
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