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Staphylococcus Infections
Researchers from Hirosaki University, Medical Department provide details of new studies and findings in the area of Staphylococcus infections
February 25th, 2009
"Staphylococcal enterotoxins (SEs) are the most common cause of foodborne diseases and toxic shock throughout the world. However, no vaccine that prevents emesis induced by SEs has been described," researchers in Hirosaki, Japan report. "A nontoxic mutant of SEA, SEAD227A, was constructed by site-directed mutagenesis and was purified by means of the Escherichia coli expression system. House musk shrews, a small emetic animal model, were immunized with SEAD227A and then challenged with wild-type SEA. SEA- induced emesis was recorded for 3 h. Antibody production was analyzed by gel double-immunodiffusion assay. Neutralizing activities of the antibodies with respect to...
Source: Vaccine Weekly (2009-02-25)
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