Immunization
Data on immunization reported by researchers at Wake Forest University, Medical Department
Published in Vaccine Weekly, March 4th, 2009
According to a study from the United States, "Transcription factors and chromatin structural modifiers induce clinically relevant epigenetic modifications of blood leukocytes during severe systemic inflammation (SSI) in humans and animals. These changes affect genes with distinct functions, as exemplified by the silencing of a set of acute proinflammatory genes and the sustained expression of a group of antimicrobial and anti-inflammatory genes."
"This paradigm is closely mimicked in the THP-1 human promonocyte cell model of lipopolysaccharide (LPS) endotoxin tolerance. We previously reported that LPS-induced de novo expression of RelB is required for generating...
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Source: Vaccine Weekly (2009-03-04)
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