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Obesity and Diabetes Vaccines
Study data from University of California update understanding of obesity and diabetes vaccines
March 4th, 2009
Data detailed in 'Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization' have been presented. According to a study from the United States, "Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads to an anti-mitochondrial antibody response and autoimmune cholangitis, similar to human primary biliary cirrhosis (PBC). We have suggested that this loss of tolerance can be induced either via chemical xenobiotic immunization or exposure to select bacteria." "Our work has also highlighted the importance of genetic susceptibility. Using the non-obese diabetic (NOD) congenic...
Source: Vaccine Weekly (2009-03-04)
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