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Vaccine Weekly

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Salmonellosis Vaccines



Findings in salmonellosis vaccines reported from Arizona State University, Center for Infectious Diseases



March 4th, 2009

Fresh data on salmonellosis are presented in the report 'Salmonella enterica serovar typhimurium strains with regulated delayed attenuation in vivo.' According to recent research from the United States, "Recombinant bacterial vaccines must be fully attenuated for animal or human hosts to avoid inducing disease symptoms while exhibiting a high degree of immunogenicity. Unfortunately, many well-studied means for attenuating Salmonella render strains more susceptible to host defense stresses encountered following oral vaccination than wild-type virulent strains and/or impair their ability to effectively colonize the gut-associated and internal lymphoid tissues."

"This thus...


Source: Vaccine Weekly (2009-03-04)

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