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Vaccine Weekly

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Acute Viremia



New acute viremia study findings have been published by scientists at National Institutes of Health



March 4th, 2009

"Cell-mediated immunity and neutralizing antibodies contribute to control of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but the role of nonneutralizing antibodies is not defined. Previously, we reported that sequential oral/oral or intranasal/oral (I/O) priming with replication-competent adenovirus type 5 host range mutant (Ad5hr)-SIV recombinants, followed by intramuscular envelope protein boosting, elicited systemic and mucosal cellular immunity and exhibited equivalent, significant reductions of chronic viremia after rectal SIVmac251 challenge," investigators in the United States report.

"However, I/O priming gave significantly...


Source: Vaccine Weekly (2009-03-04)

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