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Cancer Vaccines
New cancer vaccines findings from A. Wallecha and co-researchers published
March 4th, 2009
According to a study from the United States, "Listeria monocytogenes has been exploited previously as a vaccine vector for the delivery of heterologous proteins such as tumor-specific antigens for active cancer immunotherapy. However, for effective use of live vector in clinics, safety is a major concern." "In the present study, we describe an irreversibly attenuated and highly immunogenic L. monocytogenes platform, the L. monocytogenes dal-, dat-, and actA-deleted strain that expresses the human prostate-specific antigen (PSA) using an antibiotic resistance marker-free plasmid (the dal dat Delta actA 142 strain expressing PSA). Despite limited in vivo survival, the dal...
Source: Vaccine Weekly (2009-03-04)
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