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Chemotherapy
Research results from M. Indrova and colleagues update understanding of chemotherapy
March 4th, 2009
"We have examined the effect of IL-12-producing cellular vaccines on the cytotoxicity and proliferative potential of CD45(+) tumour-infiltrating cells (TIL) in mice carrying syngeneic TC-1 and TC-1/A9 HPV 16-associated tumours after chemotherapy with CBM-4A ifosfamide derivative," researchers in Prague, Czech Republic report. "The chemotherapy resulted in the decrease of the CD4(+) and CD8(+) TIL, increase of the Gr-1(+)/CD11b(+) TIL, no changes in the infiltration with CD4(+)/CD25(+) Treg TIL, and decrease of the cytolytic and proliferative potential of the CD45(+) TIL. Subsequent immunotherapy with the IL-12-producing, genetically modified TC-1 (TC-1-IL-12) cells...
Source: Vaccine Weekly (2009-03-04)
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