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DNA Vaccines
New findings reported from University of Massachusetts, Medical Department describe advances in DNA vaccines
March 4th, 2009
"After more than 30 years of research a HIV vaccine is still not at hand. DNA vectors expressing viral antigens are very safe vaccines, but so far they have not been efficient enough to induced broad protective immunity against retroviruses," scientists writing in the journal Viral Immunology report. "One strategy to enhance the efficiency of DNA vaccines is to augment effector T-cell priming against viral components by manipulating regulatory T-cell functions (Treg). Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a molecule that is constitutively expressed on CD4(+) Treg cells, and antibodies or natural ligands binding this molecule can impair...
Source: Vaccine Weekly (2009-03-04)
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