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Gene Therapy
Studies from C. Paula and co-researchers yield new data on gene therapy
March 4th, 2009
According to a study from Porto Alegre, Brazil, "It is known that immune system functions decrease with age, and that adaptive immune responses, especially CD4+ T cell function, seem to be the main affected point in immunity with aging. Dendritic cells (DC) are the major antigen presenting cell (APC), and at least part of the defects observed in adaptive immunity of aged individuals could be due to diminished potential of bone marrow to generate new DC, or defects in DC function." "In this study, we investigated if the ability of aged bone marrow (BM) to generate new DC in vitro, as well as aged BM-derived DC responses to lypopolysaccharide (LPS). Because DC are...
Source: Vaccine Weekly (2009-03-04)
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