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Herpes Simplex Virus
Studies from St. Louis University, Medical Department provide new data on herpes simplex virus
March 4th, 2009
"Herpes simplex virus 2 (HSV-2) and, to a lesser extent, HSV-1 cause the majority of sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available," investigators in the United States report. "Replication-defective HSV stimulates immune responses in animals but produces no progeny virus, making it potentially useful as a safe form of live vaccine against HSV. Because it does not replicate and spread in the host, however, replication-defective virus may have relatively limited capacity to solicit professional antigen presentation. We previously demonstrated that in mice devoid of B7-1 and B7-2 costimulation molecules,...
Source: Vaccine Weekly (2009-03-04)
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