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HIV/AIDS
Research from Johns Hopkins University in HIV/AIDS provides new insights
March 4th, 2009
"The glycosylation state of envelope glycoproteins in human and simian immunodeficiency viruses (HIV/SIV) is critical to viral infectivity and tropism, viral protein processing, and in virus evasion of the immune system. Using a rapid fluorescent 2-D gel-based method coupled with enzymatic pre-treatment of virus with PNGase F (Peptide: N-Glycosidase F) and fluorescent 2-D gels or 2-D gel Western blotting, we show significant differences in the glycosylation patterns of two SIV strains widely used in animal models of HIV disease and vaccine studies," scientists in the United States report. "We also demonstrate the modification of a host protein important in HIV biology...
Source: Vaccine Weekly (2009-03-04)
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