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Cancer
New cancer study results from W. Xing et al described
March 11th, 2009
"Herpes simplex virus thymidine kinase (HSV-TK) gene and dendritic cells (DC) have been used as the pioneering in cancer therapy. HSV-TK gene can induce apoptosis and necrosis in tumor cells in the presence of the non-toxic prodrug ganciclovir (GCV)," scientists writing in the journal Cellular Immunology report. "We investigated the anti-tumor effect of DC vaccination by introducing dying cells from HSV-TK gene treatment as an adjuvant. HepG(2)-TK cell line was established by transfecting human hepatoma cell line HepG(2) (HLA-A(2) positive) with HSV-TK gene. Dying tumor cells were generated by culturing HePG(2)-TK cells with GCV. After engulfed dying cells...
Source: Vaccine Weekly (2009-03-11)
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