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Life Sciences
Study results from Vrije University, Medical Department broaden understanding of life sciences
March 11th, 2009
According to recent research published in the Journal of Immunology, "A20 is a zinc finger protein with ubiquitin-modifying activity. A20 has been described as negatively regulating signaling induced by the TNF receptor and TLR family in a number of cell types, including mouse bone marrow-derived dendritic cells (DiCs)." "However, the expression and effect of A20 in activated human monocyte-derived DCs have not been previously evaluated. We report that DCs activated with the TLR3 ligand poly(I:C) up-regulate A20. Down-regulating A20 demonstrated its role in the functional activation of DCs. A20 down-regulated DCs showed higher activation of the transcription...
Source: Vaccine Weekly (2009-03-11)
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