Immunization

Investigators at University of Pennsylvania, Medical Department release new data on immunization

Published in Vaccine Weekly, March 11th, 2009

In this recent report, researchers in the United States conducted a study "Toll-like receptors contribute to the establishment of adaptive immune responses. The reported studies were conducted to examine the effects of the Toll-like receptor (TLR)-7 ligand, resiquimod, on human naive B-cell differentiation."

"Naive human B cells were cultured with resiquimod in the presence or absence of IL-2 and IL-10. Secreted IgM and IgG were measured by ELISA, and IL-6, IL-10, and IFN-alpha were measured by a multiplex protein array. Cell proliferation was assessed by measuring [3 H]thymidine uptake. mRNA for activation-induced cytidine deaminase and I-gamma 1-C-mu circle...

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Source: Vaccine Weekly (2009-03-11)

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