Cancer Gene Therapy

Data on cancer gene therapy described by K.J. Kelly et al

Published in Vaccine Weekly, March 25th, 2009

According to a study from the United States, "There is a clinical need for improved intraoperative detection of lymph node metastases from malignant melanoma (MM). We aimed to investigate the use of recombinant vaccinia virus 1h68, expressing green fluorescent protein (GFP), for real-time intraoperative detection of melanoma lymph node metastases in an immunocompetent animal model."

"Mice bearing foot pad tumors received intratumoral injections of GLV-1h68, and 48 hr later were evaluated for popliteal lymph node metastasis using noninvasive bioluminescence imaging and fluorescence imaging. Histologic analysis of lymph nodes was performed to determine sensitivity and...

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Source: Vaccine Weekly (2009-03-25)

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