Cancer Vaccines
Researchers at University of Cincinnati target cancer vaccines
Published in Vaccine Weekly, March 25th, 2009
"Immunostimulatory DNA containing unmethylated cytosine-guanine (CpG) motifs have been successfully used as adjuvants to enhance the immunity of vaccines designed to trigger antitumor T-cell responses. We examined the effect of a CpG oligodeoxynuscleotide (CpG ODN) for its ability to potentiate the activity of tumor antigen-pulsed dendritic cells (DC) in a clinically relevant mouse model, which is transgenic for both carcinoembryonic antigen (CEA) and HLA-A2 for the treatment of colon carcinoma in it therapeutic setting," scientists in the United States report.
"The systemic administration of CpG ODN 1826 alone had modest effect on tumor growth when tumors were palpable...
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Source: Vaccine Weekly (2009-03-25)
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