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Vaccine Weekly

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Cancer Vaccines



Studies from M.M. Seavey and co-authors have provided new information about cancer vaccines



March 25th, 2009

"The aim of this study was to efficiently design a novel vaccine for human Her-2/neu-positive (hHer-2/neu) breast cancer using the live, attenuated bacterial vector Listeria monocytogenes. Three recombinant L. monocytogenes-based vaccines were generated that could express and secrete extracellular and intracellular fragments of the hHer-2/neu protein," scientists in the United States report.

"In addition, we generated a fourth construct fusing selected portions of each individual fragment that contained most of the human leukocyte antigen (HLA) epitopes as a combination vaccine (L. monocytogenes - hHer-2/neu chimera). Each individual vaccine was able to either fully...


Source: Vaccine Weekly (2009-03-25)

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