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Life Sciences
Studies from University of Alabama, Medical Department in the area of life sciences published
March 25th, 2009
According to recent research from the United States, "As part of a program to identify new compounds that have activity against orthopoxviruses, a number of 4'-thionucleosides were synthesized and evaluated for their efficacies against vaccinia and cowpox viruses. Seven compounds that were active at about 1 mc M against both viruses in human cells but that did not have significant toxicity were identified." "The 5-iodo analog, 1-(2-deoxy-4-thio-beta-D-ribofuranosyl)-5-iodouracil (4'-thioIDU), was selected as a representative molecule; and this compound also inhibited viral DNA synthesis at less than 1 mc M but only partially inhibited the replication of a recombinant...
Source: Vaccine Weekly (2009-03-25)
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