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Immunization
Reports outline immunization study results from S. Kumari et al
April 1st, 2009
"Leishmania, naturally residing in the phagolysosomes of macrophages, is a suitable carrier for vaccine delivery. Genetic complementation of these trypanosomatid. protozoa to partially rectify their defective heme-biosynthesis renders them inducible with delta-amino-levulinate to develop porphyria for selective photolysis, leaving infected host cells unscathed," scientists writing in the European Journal of Immunology report. "Delivery of released ''vaccines'' to antigen-presenting cells is thus expected to enhance immune response, while their self-destruction presents added advantages of safety. Such suicidal L. amazonensis was found to confer immunoprophylaxis...
Source: Vaccine Weekly (2009-04-01)
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