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Immunization
Research conducted at D.M. Granoff and co-authors has provided new information about immunization
April 1st, 2009
According to a study from the United States, "Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal activity. We investigated the species specificity of fH binding and the effect of human fH on downregulating rat ( relevant for animal models) and rabbit ( relevant for vaccine evaluation) complement activation. Binding to N. meningitidis was specific for human fH ( low for chimpanzee fH and not detected with fH from lower primates)." "The addition of human fH decreased rat and rabbit C3 deposition on the bacterial surface and decreased group C bactericidal titers...
Source: Vaccine Weekly (2009-04-01)
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