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Myeloma
New myeloma study results from Tel-Aviv University described
April 1st, 2009
"Multiple myeloma is an incurable plasma cell malignancy. Immunotherapy in myeloma patients had limited success to date," scientists in Tel Aviv, Israel report. "We have previously demonstrated that dendritic cells (DCs) pulsed with autologous Ig Id induced Id-reactive CD8(+) T cells and protection against a myeloma tumor challenge. In this work, we studied the therapeutic efficacy of chemotherapy combined with different formulations of DC-based vaccines in mice bearing large plasma cell tumors. The comparative study demonstrated that s.c. injection of DCs loaded with Id coupled to keyhole limpet hemocyanin, s.c. injection of DCs loaded with irradiated tumor cells, and...
Source: Vaccine Weekly (2009-04-01)
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