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Pancreas
Research from University of Bonn has provided new information about pancreas
April 1st, 2009
"To study B-cell tolerance against non-lymphoid tissue autoantigens, we generated transgenic rat insulin promoter (RIP)-OVA/hen egg lysozyme (HEL) mice expressing the model antigens, OVA and HEL, in pancreatic islets. Their vaccination with OVA or HEL induced far less auto-Ab titers compared with non-transgenic controls," scientists writing in the European Journal of Immunology report. "Depletion of CD25(+) cells during immunization completely restored auto-Ab production, but did not affect antibodies against a foreign control antigen. Depletion at later time-points was not effective. OVA-specific CD25(+) FoxP3(+) T-reg were more frequent in the...
Source: Vaccine Weekly (2009-04-01)
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