Vaccine Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Enzyme Research
Researchers from Trinity College detail new studies and findings in the area of enzyme research
April 1st, 2009
"Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) (PLG) and polystyrene microparticles, dramatically enhance secretion of interleukin-1 beta (IL-1 beta) by dendritic cells (DCs)," investigators in Dublin, Ireland report. "The ability of particulates to promote IL-1 beta secretion and caspase 1 activation required particle uptake by DCs and NALP3. Uptake of microparticles induced lysosomal damage, whereas particle-mediated enhancement of IL-1 beta secretion required phagosomal acidification and...
Source: Vaccine Weekly (2009-04-01)
|
