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Life Sciences
Reports on life sciences findings from H.M. Rowe and co-researchers provide new insights
April 1st, 2009
According to recent research from London, the United Kingdom, "Lentiviral vectors deliver antigens to dendritic cells (DCs) in vivo, but they do not trigger DC maturation. We therefore expressed a viral protein that constitutively activates NF-kappa B, vFLIP from Kaposi's sarcoma-associated herpesvirus (KSHV), in a lentivector to mature DCs. vFLIP activated NF-kappa B in mouse bone marrow-derived DCs in vitro and matured these DCs to a similar extent as lipopolysaccharide; costimulatory markers CD80, CD86, CD40, and ICAM-1 were upregulated and tumor necrosis factor alpha and interleukin-12 secreted." "The vFLIP-expressing lentivector also matured DCs in vivo. When we...
Source: Vaccine Weekly (2009-04-01)
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