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Vaccines
New vaccines study findings reported from Emory University, Emory Vaccine Center
April 8th, 2009
"Chronic immunodeficiency virus infections are characterized by dysfunctional cellular and humoral antiviral immune responses(1-3). As such, immune modulatory therapies that enhance and/or restore the function of virus-specific immunity may protect from disease progression," researchers in the United States report. "Here we investigate the safety and immune restoration potential of blockade of the co-inhibitory receptor programmed death 1 (PD-1) 4,5 during chronic simian immunodeficiency virus (SIV) infection in macaques. We demonstrate that PD-1 blockade using an antibody to PD-1 is well tolerated and results in rapid expansion of virus-specific CD8 T cells with...
Source: Vaccine Weekly (2009-04-08)
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